COVID-19 vaccine coverage and the necessity of its urgent development towards Omicron the new SARS CoV-2 B.1.1. 529 variant

A SARS-CoV-2 variant belonging to Pango lineage B.1.1.529 with a significant number of S-gene mutations compared the original virus was found in early November 2021. On 26th 2021, World Health Organization (WHO) designated mutation as concern and assigned it name Omicron. The difference is identified by 30 changes spike protein, three minor deletions, one insertion, 15 which are receptor-binding area. Omicron most diverging variety discovered substantial numbers so far during pandemic, raising concerns that may be associated reductions vaccination efficacy an increased risk reinfections. pseudo- or live isolates urgently needed understand better virus's escape potential against both vaccination, infection-acquired immunity required.